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. 2013 Jan 2;33(1):286–291. doi: 10.1523/JNEUROSCI.3515-12.2013

Figure 2.

Figure 2.

Comparison of expected to observed DRD4 genotypes. Oldest-old individuals (N = 310) were genotyped at the exon 3 DRD4 polymorphism (Fig. 1, inset) and compared with population-based European ancestry control sample DRD4 genotypes (Expected, N = 2902). The DRD4 7R/x category (black bars) contains individuals with at least one 7R (or derived 7R, i.e., 5R, 6R, 8R, 9R, 10R, and 11R) allele, and the non-7R/x category (striped bars) contains the remaining individuals. The expected and observed fraction for each category is shown. Expected 7R/x (N = 635), Non 7R/x (N = 2267); 90+ observed 7R/x (N = 113), Non 7R/x (N = 197); Female 7R/x (N = 86), Non 7R/x (N = 133); Male 7R/x (N = 27), Non 7R/x (N = 64). Asterisks denote observed differences significant at p = 3.5 × 10−9 (90+ years), p = 1.7 × 10−9 (Female), and p = 0.034 (Male) (see text).