Figure 5.
Spontaneous locomotor activity for different ages in WT, HT, and KO mice reared in a DE and an EE. Values correspond to means (±SE) and correspond to average activity over 90 min. The genotype-by-age interaction on locomotor activity was significant (F = 3.61, p < 0.001, ηp2 = 0.034) with overall significantly lower activity levels for KO mice than for WT or HT mice (p < 0.05). The interaction of environment by age with locomotor activity was also significant (F = 2.77, p = 0.017, ηp2 = 0.013); overall, DE mice were significantly more active than EE mice (p < 0.05). However, since animals in an EE decrease in spontaneous locomotor activity (Garland et al., 2011) and we did not record 24 h activity levels, we cannot compare activity levels across the two environmental conditions.