Figure 13.

LM11A-31 attenuates the apoptotic response after SCI via targeting p75. A, JNK3 activity was decreased with LM11A-31 at 100 mg/kg. JNK3 activity was measured in immunoprecipitation/kinase assays. B, Quantification of JNK3 activity. *p < 0.05 (Student's t test). C, Cytochrome c release from the mitochondria was decreased with LM11A-31 at 100 mg/kg compared with 0 mg/kg. D, Quantification of cytochrome c levels in the cytosol; p values were obtained by Student's t test. E, LM11A targets p75 after SCI. JNK3 activity was measured in p75^−/− mice with and without 100 mg/kg LM11A-31. F, Quantification of JNK3 activity. *p < 0.05 (Student's t test).