Table 2.

Impact of Age Cutoffs on LS Screen/Test Outcomes, at 100% and 50% Confirmatory Testing Acceptance Rates (N = 325 patients with CRC)

Variable	No Age Cutoff		80 Years		70 Years		60 Years		50 Years
	100% Acceptance Rate	50% Acceptance Rate	100% Acceptance Rate	50% Acceptance Rate	100% Acceptance Rate	50% Acceptance Rate	100% Acceptance Rate	50% Acceptance Rate	100% Acceptance Rate	50% Acceptance Rate
Total cost to screen and test this age cohort	$113,123	$100,711	$97,808	$87,076	$72,747	$64,765	$46,293	$41,214	$17,752	$15,804
No. of LS cases present in entire CRC cohort	11.7	11.7	11.7	11.7	11.7	11.7	11.7	11.7	11.7	11.7
No. of LS cases expected in screened cohort	11.7	11.7	11.2	11.2	10.1	10.1	9.0	9.0	5.9	5.9
Mean No. of LS cases expected to be identified in screened cohort	10.7	5.4	10.2	5.1	9.2	4.6	8.3	4.1	5.4	2.7
Cost per LS case detected in screened cohort	$10,567	$18,794	$9567	$17,016	$7865	$3989	$5594	$9950	$3316	$5899
No. of LS cases missed if screening cut off at this age	1.0	6.3	1.5	6.6	2.5	7.1	3.4	7.6	6.3	9.0
No. of LS cases expected to be missed in screened cohort	1.0	6.3	0.9	6.1	0.9	5.5	0.8	4.9	0.5	3.2
LS cases that would be missed with this strategy, %	8.5	54.2	12.6	56.3	20.9	60.4	29.3	64.6	54.3	77.1

NOTE. Boldface indicates parameters the authors believe to be most important in the age cutoffs reviewed in the Discussion section.

Abbreviations: CRC, colorectal cancer; LS, Lynch syndrome.