Figure 6.
Scatter plots of the 3K model WSSE objective function, macroparameters, and individual rate parameters comparing conventional versus separable parameter space fit results for noisy populations of time-activity curves. In each case, results for three different numbers of iterations are shown for the conventional fits with simulated annealing, demonstrating convergence effects as progressively higher numbers of iterations produced successively better fits (lower WSSE) for some curves. Note that in all cases the separable parameter space fits with exhaustive search produced equal or lower WSSE than the conventional model fits to within the numerical precision of the search (approximately 1 part in 10−3). As a population, the conventional model fits approached the separable parameter space fits as the number of iterations increased.