Table 2.
Impact of 3 months Clonidine versus Placebo
| Clonidine | Placebo | |
|---|---|---|
| MSNA (bursts/min) | −4.3± 2.4 | 4.4±4.4 |
| MSNA (bursts/100HB) | −3.1±3.1 | 4.1±8.3 |
| Heart rate (bpm) | −3.5±1.5 | 0.6±5.0 |
| MAP (mmHg) | −1.6±12.0 | −10.6±5.5 |
| Citrate synthase total μmole/min/wet weight | −0.3±0.09 | 0.07±0.07 |
| Citrate synthase S1 μmole/min/100 NCP | −3.6±2.4 | 2.8±0.9 |
| Succinate cytochrome C reductase μmole/min/100 NCP | −0.5±0.5 | 0.6±0.2 |
| Cytochrome C oxidase μmole/min/100 NCP | 0.9±0.8 | 1.3±1.2 |
| NADH:O μmole/min/100 NCP | 0.3±0.2 | 2.5±1.6 |
| Fiber type 1 (%) | −4.6±3.8 | −5.6±1.9 |
| Vascular index microvessels/mm2 | −50.8±69.2 | −49.9±29.1 |
| Fiber type 1 diameter(μm) | −8.7±10.1 | 3.2±2.5 |
| Fiber type 2 diameter (μm) | −5.1±7.3 | −1.5±2.2 |
| Total fibers/mm2 | 2.5±30.8 | 10.1±9.3 |
Values are the difference between 3 months on drug or placebo and baseline. HB=heart beats, MSNA = muscle sympathetic nerve activity, NCP=non-collagen protein. Values are means±SEM. Differences were not significant for any variable.