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Figure 6. Examples of energy-minimized complexes of lidocaine (A) and tetracaine (B) with the open-inactivated KcsA structure (PDB entry 3F5W) and S1/S4 K+ occupancy of the selectivity filter. Note that the apparently different crossing angles of inner helices in the right panels of (A) vs. (B) are due to different views of the ligand-channel complex chosen for an optimal display of the LA molecule.
