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. 2004 Apr;78(7):3578–3600. doi: 10.1128/JVI.78.7.3578-3600.2004

FIG. 12.

FIG. 12.

FIG. 12.

Immune system-mediated liver injury during chronic infection of mice with LCMV. (A) C57BL/6 mice were infected with 2 × 106 PFU of LCMV-Docile, and liver tissues recovered on days 9 (b), 15 (c), 21 (d), 28 (e), and 35 (f) after infection were fixed in acetone, sectioned, and stained with hematoxylin and eosin. Liver tissues from uninfected mice (a) were used as a control. Arrows indicate periportal mononuclear infiltrates in tissues of infected mice. Original magnification, ×200. (B) Liver-specific enzyme activities in serum (sALT and sAST) were measured over a period of 35 days after the infection of mice with 2 × 106 PFU of LCMV-Docile (•). Control values from sera of uninfected mice are also shown (○). Data shown are means ± SEM of enzymatic activities (units per liter) of three individual mice.