Table 3.
Summary of toxicities
| Toxicity, N (%) | Worst grade N = 11
|
|||
|---|---|---|---|---|
| 1/2 | 3 | 4 | 5 | |
| Leukopenia | 6 (55) | 2 (18) | 1 (9) | |
| Neutropenia | 3 (27) | 1 (9) | ||
| Lymphopenia | 1 (9) | 2 (18) | 8 (73) | |
| CD4 counta | 1 (14) | 6 (86) | ||
| Hemoglobin | 3 (27) | 2 (18) | 1 (9) | |
| Platelets | 6 (55) | 1 (9) | ||
| Infection | 1 (9) | 3 (27) | ||
| Hypersensitivity | 2 (18) | |||
| Rash | 4 (36) | |||
| Diarrhea | 4 (36) | 1 (9) | ||
| Nausea | 4 (36) | 1 (9) | ||
| Vomiting | 2 (18) | |||
| Mucositis | 2 (18) | 1(9) | ||
| Constitutional | 2 (18) | 5 (45) | ||
| Metabolic | 5 (45) | 1 (9) | ||
| Pulmonary | 2 (18) | 2 (18) | ||
1 patient had DLT on dose level 2 (fatigue, dyspnea–grade 3)
a
Percentages for CD4 Count use a denominator of 7, the number of patients evaluated for CD4 toxicity