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. 2013 Jul 10;14:467. doi: 10.1186/1471-2164-14-467

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Copyright © 2013 Yang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Differential parasite gene expression between type I strains. (A) The top five enriched Gene Ontology (GO) pathways using GSEA in differentially expressed parasite genes in RH-ERP compared to RH-JSR/GT1 and the corresponding GSEA diagrams, using Toxoplasma genesets with Gene Ontology annotations. The GSEA diagrams show the enrichment score (green line), which reflects the degree to which that particular gene set (header above) is overrepresented in the differentially expressed genes between RH-ERP and RH-JSR/GT1 (ranked by their differential expression values). The middle portion of the diagram shows where the members of the particular gene set appear in the ranked gene list. The bottom portion of the diagram shows the value of the ranking metric, which measures the correlation of a gene with upregulation (positive value) or downregulation (negative value) in RH-ERP compared to RH-JSR/GT1. (B) The top five enriched InterPro domain using GSEA in differentially expressed parasite genes in RH-ERP compared to RH-JSR/GT1 and the corresponding GSEA diagrams, using Toxoplasma genesets with InterPro annotations.