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. 2004 Apr;78(7):3797–3802. doi: 10.1128/JVI.78.7.3797-3802.2004

FIG. 1.

FIG. 1.

(A) Amino acid sequences of the C-terminal transmembrane domain (amino acids 571 to 591) of HCV and BVDV NS5Bs (23, 34). Underlined boldface letters correspond to residues observed in more than 10% of the 307 HCV isolates (34). The rest occurred infrequently. Sequences are listed in decreasing order of observed frequency from top to bottom. Numbers above amino acid sequences represent amino acid positions in HCV and BVDV NS5Bs. (B) Schematic diagrams of the NS5B mutants in various replicons used in this study. Open and gray boxes represent HCV and BVDV NS5B transmembrane domains (TMD), respectively. Angled and straight lines represent the deletion and a noncoding RNA, respectively.