Table 7.
Deaths during the RENEW study
|
Count |
Age (years)/ |
Form |
Baseline |
Cause(s) |
Study phase |
Treatment |
Cumulative |
|---|---|---|---|---|---|---|---|
| gender | of MS | EDSS | related? | dose mg/m2 | |||
| 1 |
51/F |
SPMS |
7 |
Pneumonia |
Treatment |
No |
91.3 |
| 2 |
43/F |
SPMS |
6 |
Decreased ejection fraction, |
Treatment |
Probable |
96.8 |
| cardiomyopathy, congestive heart | |||||||
| failure | |||||||
| 3 |
50/F |
SPMS |
8.5 |
Pulmonary embolism |
Treatment |
No |
12.2 |
| 4 |
57/M |
SPMS |
7 |
Road traffic accident |
Annual follow-up |
No |
99.7 |
| 5 |
57/M |
SPMS |
6 |
Prostate cancer |
Treatment |
No |
Unknown |
| 6 |
49/M |
SPMS |
6.5 |
Cerebrovascular accident, carotid |
Annual follow-up |
Possible |
119.4 |
| artery occlusion | |||||||
| 7 |
57/M |
PRMS |
7 |
Pulmonary edema |
Annual follow-up |
Unknown |
109.5 |
| 8 |
55/F |
SPMS |
6.5 |
Pulmonary embolism |
Annual follow-up |
No |
67.7 |
| 9 |
51/F |
RRMS |
4 |
Acute meningitis |
Treatment |
Possible |
11.9 |
| 10 |
68/M |
SPMS |
7.5 |
Respiratory failure |
Treatment |
No |
11.1 |
| 11 |
37/F |
SPMS |
9 |
Cardiopulmonary arrest |
Treatment |
No |
18.4 |
| 12 | 44/F | SPMS | 7 | Septic shock | Treatment | Possible | 81.9 |
EDSS=Expanded Disability Status Scale; F=female; M=male; MS=multiple sclerosis; PRMS=progressive relapsing multiple sclerosis; RENEW=Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis; SPMS=secondary progressive multiple sclerosis.