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. 2004 Apr;78(7):3333–3342. doi: 10.1128/JVI.78.7.3333-3342.2004

FIG. 2.

FIG. 2.

Protein-specific immune responses of immunized macaques. Tat-, Env-, and Gag-specific immune responses of Tat-Env-Gag-immunized animals (group A [EEG, WJ8, R300, and Ri178]) are displayed on the left site of the dashed line. Tat-specific immune responses of Tat-immunized animals (group B [R113, R357, 94059, and 95053]) are presented on the right site of the dashed line. From top to bottom, the number of antigen-specific IFN-γ-, IL-2-, and IL-4-secreting cells; antigen-specific lymphoproliferation (LP); and antibody (Ab) titers are depicted. The Env- and Gag-specific cell-mediated immune responses of Tat-immunized group B animals were negative and are not shown. At the bottom, the first horizontal line represents the time points of DNA immunization (weeks 0, 2, and 6), the second horizontal line represents the times of protein boosts (weeks 10, 14, and 24), and the arrow indicates the time of challenge (week 32).