TABLE 1.
Mouse straina | Outcome of infection withb:
|
|
---|---|---|
BHV-1 | BHV-5 | |
Wild typec | No diseased | No diseased |
A129e | No diseased | No diseased |
AG129f | No diseased | No diseased |
AR129g | No diseaseh | Disease and death (dpi 16)i |
AGR129k | Disease and death (dpi 16)l | Disease and death (dpi 11)l |
GR129 | Not done | No diseasem |
All mouse strains are derived from strain 129Sv/Ev.
Mice were infected intraperitoneally with 107 TCID50 of the indicated virus.
Wild-type mice with normal innate and adaptive defense systems.
No disease signs for at least 43 dpi; antiviral antibodies detectable.
Mice with genetically deleted alpha/beta interferon receptor.
Mice with genetically deleted alpha/beta and gamma interferon receptors.
Mice with genetically deleted alpha/beta interferon receptor combined with RAG-2 knockout.
No disease signs until the end of the experiment at dpi 21.
Symptoms of central nervous disease as described in the text. The time of onset of disease is indicated in parentheses.
Mice with genetically deleted alpha/beta and gamma interferon receptors combined with RAG-2 knockout.
Disease signs and death as described in the text.
No disease signs for at least 43 dpi.