Table 1. HNSCC Tumors with Multiple Mutations in a Single Mitogenic Pathway.
Describes all tumors in our cohort harboring mutations in more than one gene in a defined mitogenic pathway by mutation type and pathological stage.
| Pathway | Tumor | Annotated Genes |
Amino Acid Change |
TNM Stage/Overall Staging |
|---|---|---|---|---|
| PI3K | HN_00190 | PIK3C2G | p.V656L | T1N2bM0/ Stage 4 |
| Pathway | PTEN | p.D92E | ||
| HN_62421 | PIK3R1 | p.D560H | T4N0M0/ Stage 4 | |
| MTOR | p.L2260H | |||
| HN_62469 | PIK3CA | p.H1047R | T2N2bM0/ Stage 4 | |
| MTOR | p.R1161Q | |||
| HN_63039 | PIK3CA | p.H1047L | T4N2bM0/ Stage 4 | |
| PTEN | p.R335* | |||
| HN_22PT | PIK3CG | p.G491E | T4aN2bM0/ Stage 4 | |
| PIK3AP1 | p.G313R | |||
| HNPTS_1 | PTEN | p.R14S | T4N0M0/ Stage 4 | |
| PIK3IP1 | p.A144S | |||
| PIK3CA | p.E545K | |||
| HNPTS_29 | PIK3C2G | p.S1272L | T4N2bM0/ Stage 4 | |
| PIK3R5 | p.E322K | |||
| PIK3CA | p.E542K | |||
| HNPTS_38 | PIK3R5 | p.E60* | T4N2M0/ Stage 4 | |
| PIK3CA | p.H1047R | |||
| HNPTS_42 | TSC2 | p.S1514* | T4N2BM0/ Stage 4 | |
| PIK3CA | p.E545K | |||
| PIK3CG | p.A156V | |||
| HNPTS_45 | AKT2 | p.Y351C | T4N1M0/ Stage 4 | |
| PIK3CA | p.H1047R | |||
| JAK/STAT | HN_63080 | JAK3 | p.R948C | T4aN2bM0/ Stage 4 |
| Pathway | STAT1 | p.Q330K | ||
| MAPK | NONE | |||
| Pathway | ||||