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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2013 May 29;86(5):969–977. doi: 10.1016/j.ijrobp.2013.04.028

Figure 4.

Figure 4

ATMR-NLS demonstrates enhanced sensitivity compared to the ATMR. (a) Treatment of 293 cells bearing either a control luciferase (Luc), ATMR, ATMR-NLS, or ATMR-NLSmut for one hour with CGK-733 (10 μM), followed by assaying for bioluminescence. (b) 293 cells bearing various reporters were irradiated with 2 Gy and bioluminescent activity was monitored at 5, 10, 15, 30, 60, and 120 min after radiation. Data are normalized to values from 293-Luc cells, asterisks indicate p-value < 0.05 compared to 293-Luc cells, and § indicates p-value < 0.05 compared to 293-ATMR cells. Error bars are s.e.m.