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Reovirus-specific IgG2a (closed bars) and IgG1 (open bars) serum antibody concentrations following mucosal or parenteral infections. BALB/c mice were infected with reovirus orally, nasally, or in the FP with 3 × 106 PFU/mouse, and serum antibody responses were determined 10 days after infection. Bars indicate the standard errors among groups of three mice. The dashed line indicates the limit of detection. Data shown are from one of three similar experiments.
