FIG. 6.

Enhancement of reovirus-specific IgA production by in vivo rIL-4 treatment. BALB/c mice (solid bars) or IL-4^−/− mice (hatched bars) were infected orally with 10⁷ PFU of reovirus T1/L per mouse. Groups of mice received rIL-4 at 3 μg/dose (with or without 30 μg of a carrier/dose as noted) on day −1 and on day 2 of infection. The fragment culture supernatants were collected, and IgA concentrations were determined by reovirus-specific ELISA. Bars indicate the standard errors among groups of 4 to 10 mice from two independent experiments. The asterisk indicates a significant difference from nontreated orally infected mice as determined by one-way ANOVA and Dunn's post-hoc test (P < 0.05).