Table 4.
Expression of SDHA and SDHB according to HIF-1α expression status
| Factors | Nuclear HIF-1α | Cytoplasmic HIF-1α | ||||
|---|---|---|---|---|---|---|
| Negative n = 697 (%) | Positive n = 24 (%) | P-value | Negative n = 717 (%) | Positive n = 4 (%) | P-value | |
| Tumoral SDHA | 0.247 | 0.518 | ||||
| Negative | 40 (5.7) | 1 (4.2) | 40 (5.6) | 1 (25.0) | ||
| Low | 311 (44.6) | 8 (33.3) | 318 (44.4) | 1 (25.0) | ||
| High | 346 (49.6) | 15 (62.5) | 359 (50.1) | 50.0) | ||
| Stromal SDHA | 0.423 | 1.000 | ||||
| Negative | 644 (92.4) | 21 (87.5) | 661 (92.2) | 4 (100.0) | ||
| Positive | 53 (7.6) | 3 (12.5) | 56 (7.8) | 0 (0.0) | ||
| Tumoral SDHB | 0.926 | 0.032 | ||||
| Negative | 24 (3.4) | 0 (0.0) | 23 (3.2) | 1 (25.0) | ||
| Low | 235 (33.7) | 10 (41.7) | 243 (33.9) | 2 (50.0) | ||
| High | 438 (62.8) | 14 (58.3) | 451 (62.9) | 1 (25.0) | ||
| Stromal SDHB | 0.328 | 1.000 | ||||
| Negative | 621 (89.1) | 20 (83.3) | 637 (88.8) | 4 (100.0) | ||
| Positive | 76 (10.9) | 4 (16.7) | 80 (11.2) | 0 (0.0) | ||
SDH succinate dehydrogenase.