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. Author manuscript; available in PMC: 2013 Jul 14.
Published in final edited form as: Adv Exp Med Biol. 2012;748:283–304. doi: 10.1007/978-1-4614-3573-0_12

Fig. 12.3.

Fig. 12.3

A Venn diagram illustrating the tight coupling between neuronal activity and energy metabolism at the molecular level by having the same transcription factor, NRF-1, coregulating genes for critical glutamatergic neurochemicals (Grin1, Grin2b, Gria2, Nos1, and NR2B motor Kif17) as well as all 13 subunits of COX. Such coupling ensures that energy production exquisitely matches energy demand of neuronal activity.