Figure 4.

Pterostilbene treatment suppressed the migration and invasion of CD133⁺ Mahlavu cells. (a) CD133⁺ Mahlavu cells were treated with an increasing concentration of pterostilbene (5–15 μM). Pterostilbene treatment led to a dose-dependent suppression in the migration. (b) Similarly, the invasiveness of CD133⁺ Mahlavu cells was decreased as the concentration of pterostilbene increased. (c) Western blot analysis of pterostilbene-treated CD133⁺ Mahlavu cells. Pterostilbene-mediated suppression on migration and invasiveness were correlated to the decreased expression level of prometastasis molecules including vimentin, CXCR4 and Twist1 while the level of epithelial marker E-cadherin increased.