FIG. 6.

Comparison of S domain sequences among HBV genomes with different virion secretion efficiencies. WT, wild-type consensus sequence of genotype A (21). Such a wild-type sequence is found in clones 6.2, 7.2, and 7.4. For other clones, only mutated residues are given. The landmarks for fragment exchange (AvrII and EcoRV sites, nucleotide positions 520 and 730) are indicated. Underlined is a stretch of amino acid residues specified by fragment 520-730, the determinant for differential virion secretion between 3.4 and 4B.