TABLE 2.
Mutations in the S genes of HBV genomes and their impact on protein translation
| Clone(s) | Mutationa in:
|
||
|---|---|---|---|
| Nucleotide | S domain | Polymerase | |
| 3.4 | T176C | F8L | I363T |
| G510A | G119E | Silent | |
| T777C | I208T | Silent | |
| 4B and 4C | A273G | N40S | Silent |
| T287G | S45A | I400S | |
| T484G | I110M | S466A | |
| A496G | Silent | N470D | |
| T552C | M133T | Silent | |
| A636T | Y161F* | Silent | |
| T705C | V184A* | Silent | |
| G779T | V209L | R564L | |
| T784G | S210R | S566A | |
| 4C (not 4B) | G660C | R169P | Silent |
| 5.2 | T216C | L21S | Silent |
| T766A | S204R | S560T | |
a
Boldface, mutations that modulate virus secretion; *, wild-type sequence in some other genotypes.