Table 1.
Survival analysis, dosage and start age of treatment versus control administered to the SOD1G93A mice.
| Treatment | Dosage (mg/kg/day) | Mean Survival ± SEM (sample number) | Δ Survival | Trial | |
|---|---|---|---|---|---|
| Treated | Control | ||||
| Diapocynin | |||||
| 21 day start | 150 | a1 | |||
| Male | 126 ± 2 (12) | 127 ± 2 (12) | − 1 | ||
| Female | 130 ± 3 (12) | 133 ± 3 (12) | − 3 | ||
|
|
|||||
| Total | 128 ± 2 (24) | 130 ± 2 (24) | − 2 | ||
| Diapocynin | |||||
| 100 day start | 150 | a1 | |||
| Male | 130 ± 2 (12) | 123 ± 2 (12) + | +7 (P=<0.007) | ||
| Female | 139 ± 2 (12) | 129 ± 2 (12) + | +10 (P=<0.003) | ||
|
|
|||||
| Total | 134 ± 2 (24) | 126 ± 2 (24) + | +8 (P=<0.001) | ||
| Apocynin - antibiotics | |||||
| 21 day start | 300 | a | |||
| Male | 129 ± 2 (12) | 127 ± 3 (12) | + 2 | ||
| Female | 130 ± 2 (12) | 131 ± 2 (12) | − 1 | ||
|
|
|||||
| Total | 130 ± 2 (24) | 129 ± 2 (24) | + 1 | ||
| Apocynin + antibiotics | |||||
| 21 day start | 300 | a2 | |||
| + 100 day start | + 15 | ||||
| Male | 131 ± 3 (12) | 126 ± 2 (12) | + 5 | ||
| Female | 131 ± 2 (12) | 132 ± 2 (12) | − 1 | ||
|
|
|||||
| Total | 131 ± 2 (24) | 129 ± 2 (24) | + 2 | ||
| Apocynin dose response | |||||
| 21 day start | |||||
| 150 | 126 ± 2 (12) | 128 ± 2 (13) | − 2 | b3 | |
| 300 | 133 ± 3 (14) | + 5 | |||
| 750 | 135 ± 2 (11) | 135 ± 3 (11) | 0 | b | |
| Apocynin | |||||
| 100 day start | 300 | a | |||
| Male | 130 ± 2 (12) | 127 ± 2 (12) | + 3 | ||
| Female | 134 ± 2 (12) | 131 ± 2 (12) | + 3 | ||
|
|
|||||
| Total | 132 ± 2 (24) | 129 ± 2 (24) | + 3 | ||
| Vanillic Acid | |||||
| 21 day start | b3 | ||||
| 75 | 127 ± 5 (6) | 128 ± 2 (6) | − 1 | ||
| 150 | 133 ± 4 (4) | + 5 | |||
a
Performed at Oregon State University.
b
Performed at Medical College of Wisconsin.
1
Control group was administered saline at the specified age.
2
Antibiotics started at 100 days of age for apocynin group and control group.
3
Randomized trial of 2 treatment dosages with 1 control group.