Figure 3. Bach2 is required for suppression of lethal inflammation in a Treg-dependent manner.

a, CD44 and CD62L expression on splenic CD4⁺ T cells descended from KO BM 6 weeks following individual or mixed reconstitution of Rag1^−/− mice with KO and WT BM. b, CD3 staining of large intestine and lung tissue from mice 6 weeks following reconstitution with indicated BM. Arrows indicate KO T cells (L). c, Mass of mice following individual or mixed reconstitution of Rag1^−/− mice with BM from Scurfy (FoxP3^sf), KO or WT mice with or without transfer of 4×10⁵ purified splenic CD4⁺ CD25⁺ Treg cells. Data are representative of ≥3 independent experiments. Mass measurements were continued until <3 mice were remaining (c). Error bars s.e.m.; P values (Student’s t-test).