Table 3.
Overall phenotypic differences between HA-NL1FL and HA-NL1ΔC mice
| Assay | HA-NL1FL | HA-NL1ΔC |
|---|---|---|
| Synapse number | No Δ | ↑ Spines and PSD-95 cluster density |
| Synapse size | ↑ Spine head size | No Δ |
| SynapsinI area | ||
| Protein levels | ↑ Shank | ↑ SAP102 ↓ Sap97 |
| PICK1 | PSD-95 | |
| Sap97 | NR2B | |
| NR2A | ||
| Basal synaptic transmission | ↑ NMDAR/AMPAR | No Δ |
| τ | ||
| PP-LTP | No Δ | No Δ |
| Water maze | ↓ Reversal learning | ↑ Reversal learning |
| Social behavior | No Δ | ↓ Aggression |
| Social novelty | ||
| Preference |
Left column summarizes effects of interest compared between our mice. Middle and right columns summarize whether a change in the phenotype is measured, and arrows delineate sign of change relative to controls.