Figure 2.

Spatial Distribution of Genetic Variants at the Functional-Domain-Encoding Region of APOL1

The APOL1 genetic region, which codes for the pore-forming (blue), membrane-addressing (green), and SRA-interacting (orange) domains, and the adjacent intron are marked by genetic variants identified in this study. Each synonymous and intronic SNP is labeled by a gray line. Each nonsynonymous SNP is labeled by a black line with its genomic position (based on NCBI Genome browser build 36.1) and reference SNP ID if it is described in dbSNP. For those nonsynonymous SNPs that are not present in dbSNP (build 137), the changes of nucleotide state are given according to RefSeq NG_023228.1. The indel variant (i.e., G2 allele) is labeled by an inverted triangle. The nucleotide site of each variant at our sequence alignment is labeled at the bottom of the gene. The nucleotide sites that define the G3 haplotype are labeled with asterisks.