Table 1.
Simulation Study Settings
|
Sample Sizesa |
Covariatesb |
||||||
|---|---|---|---|---|---|---|---|
| Scenario | Pop.c | Study 1 | Study 2 | Study 3 | Study 1 | Study 2 | Study 3 |
| Different Cohort Sizes | |||||||
| 1 | EUR | 1,600 (800, 800) | 2,200 (1,000, 1,200) | 3,200 (1,800, 1,400) | (X1, X2) | (X1, X2) | (X1, X2) |
| 2 | EUR | 1,600 (800, 800) | 2,200 (1,000, 1,200) | 3,200 (1,800, 1,400) | (X1) | (X1, X2) | (X1, X2, X2) |
| 3 | EUR+AA | 1,600 (800, 800) | 2,200 (1,000, 1,200) | 3,200 (1,800, 1,400) | (X1) | (X1, X2) | (X1, X2, X2) |
| Equal Cohort Sizes | |||||||
| 4 | EUR | 2,400 (1,000, 1,400) | 2,400 (1,000, 1,400) | 2,400 (1,000, 1,400) | (X1, X2) | (X1, X2) | (X1, X2) |
| 5 | EUR | 2,400 (1,000, 1,400) | 2,400 (1,000, 1,400) | 2,400 (1,000, 1,400) | (X1) | (X1, X2) | (X1, X2, X2) |
| 6 | EUR+AA | 2,400 (1,000, 1,400) | 2,400 (1,000, 1,400) | 2,400 (1,000, 1,400) | (X1) | (X1, X2) | (X1, X2, X2) |
a
Total sample sizes, with numbers of cases and controls in the parentheses for simulation of binary traits.
b
Number of covariates in each study.
c
EUR refers to the scenario where all three studies had EUR samples. EUR + AA refers to the scenario where studies 1 and 2 had EUR samples and study 3 had AA samples.