Figure 7.

The Fraction of All Genome-wide Nonreference Homozygotes Falling in ROH Regions for Nondamaging Variants, Nonsense Variants, and LoF Nonsense Variants versus the Fraction of the Genome Covered by ROH, for Individuals Grouped into “Low-ROH” and “High-ROH” Groups

(A) Any ROH region.

(B) Short (class A) ROH regions.

(C) Medium (class B) ROH regions.

(D) Long (class C) ROH regions.

Means that exceed the mean for benign sites for the same ROH coverage class at the p < 0.05 significance level are indicated by asterisks.