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. 2013 Jun 24;110(28):11589–11594. doi: 10.1073/pnas.1304365110

Fig. 3.

Fig. 3.

Locomotor-like activity can be initiated and eliminated unilaterally. Stimulating a unilateral spot at L2 in Vglut2::Cre; RC-ChR2 mice elicits unilateral locomotor-like activity in left and right sides consecutively (A), and this activity can be produced when the two sides are separated by cutting the ventral commissure (B; DF, dorsal funiculus; DH, dorsal horn; VH, ventral horn). (Scale bar: 100 µm.) Hyperpolarizing glutamatergic neurons unilaterally, using Vglut2::Cre; RC-eNpHR mice can abolish brainstem-evoked (BS-stim: 2 Hz, 0.5 mA) locomotor-like activity on one side of the cord, whereas activity is maintained on the side contralateral to the light (C; l and r, left and right sides, respectively).