Table 1.
Control | Hemorrhage | SNO-Hb–depleted | SNO-Hb–repleted | |
ATP | 5.6 ± 0.7 | 4.8 ± 0.4 | 4.9 ± 0.9 | 4.9 ± 0.7 |
ADP | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.6 ± 0.2* |
CrP | 17 ± 3 | 24 ± 6* | 20 ± 7 | 25 ± 2* |
Cr | 11 ± 3 | 10 ± 3 | 15 ± 3 | 12 ± 2 |
Pyr | 0.06 ± 0.02 | 0.07 ± 0.02 | 0.05 ± 0.01 | 0.05 ± 0.01 |
L | 2.5 ± 0.8 | 3.3 ± 1.5 | 4.3 ± 2.6* | 2.6 ± 1.4 |
L/Pyr | 39 ± 8 | 47 ± 22 | 87 ± 65* | 51 ± 33 |
CrP+Cr | 30 ± 5 | 35 ± 8 | 37 ± 7* | 38 ± 2* |
Muscle metabolic markers under control (n = 7), hemorrhage (n = 9), and transfusion conditions (n = 10 for both). Values followed by an asterisk (*) indicate a significant difference from control values (P < 0.05). ADP, adenosine diphosphate; ATP, adenosine triphosphate; Cr, creatine; CrP, creatine phosphate; L, lactate; L/Pry, lactate/pyruvate ratio; Pyr, pyruvate.