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. 2013 Jun 24;110(28):11511–11516. doi: 10.1073/pnas.1310144110

Fig. 6.

Fig. 6.

RHOH and RYBP are potential direct targets of miR-9. (A) Relative expression of RHOH and RYBP in normal human cord blood CD34+ cells transduced with MSCV-MLL-AF9 (MA9-1, -2, and -3), MSCV-AML1-ETO (AE-1), or empty vector (NC-1) (15). (B) Relative expression of Rhoh and Rybp in normal mouse BM progenitor cells transducted with MSCVneo-MLL-AF9+MSCVpig (MA9) or MSCVneo-MLL-AF9+MSCVpig-miR-9 (MA9+miR-9). Cells used for the analysis are passage II colony cells from the in vitro colony-forming/replating assay shown in Fig. 3A. (C) Relative expression of RHOH and RYBP in human MONOMAC-6 cells 48 h after transfection with empty vector (MSCVpig) or miR-9 (MSCVpig-miR-9). Expression level of each target gene in the control group in each plot was set to 1 for comparison and statistical analysis. *P < 0.05; **P < 0.01; two-tailed t test.