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Target sequences of HCV-specific shRNAs. The CLUSTAL W algorithm (61) was used to align the first 389 nucleotides of the HCV Con1 consensus genome (genotype 1b) with homologous sequences of six other genomes representing genotypes 1a (strain H77), 2a (strain HC-J6CH), 3a (strain NZL1), 4a (strain HEMA51), 5a (strain EUH1480), and 6b (strain Th580). Black lines indicate sequences targeted by shRNAs. Coding nucleotides are highlighted in gray.
