Table 1.
Association of asTF and flTF with patient and tumor characteristics
| Characteristic | Total N (%) | asTF- N (%)* | asTF+ N (%)* | P | flTF- N (%)* | flTF+ N (%)* | P |
| Total | 574 (100) | 119 (100) | 328 (100) | 157 (100) | 351 (100) | ||
| Age (y) | |||||||
| <40 | 48 (8.4) | 5 (4.2) | 26 (7.9) | 15 (9.6) | 26 (7.4) | ||
| 40–60 | 277 (48.3) | 72 (60.5) | 153 (46.6) | 0.03 | 75 (47.8) | 171 (48.7) | 0.71 |
| ≥60 | 249(43.4) | 42 (35.3) | 149 (45.4) | 67 (42.7) | 154 (43.9) | ||
| Missing* | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
| Grade | |||||||
| I | 81 (14.1) | 26 (21.8) | 28 (8.5) | 30 (19.1) | 41 (11.7) | ||
| II | 282 (49.1) | 58 (48.7) | 159 (48.5) | <0.001 | 88 (56.1) | 157 (44.7) | <0.001 |
| III | 203 (35.4) | 33 (27.7) | 138 (42.1) | 35 (22.3) | 149 (42.5) | ||
| Missing* | 8 (1.4) | 2 (1.7) | 3 (0.9) | 4 (2.5) | 4 (1.1) | ||
| Histotype | |||||||
| Ductal | 514 (89.5) | 104 (87.4) | 300 (91.5) | 133 (84.7) | 320 (91.2) | ||
| Lobular | 53 (9.2) | 13 (10.9) | 25 (7.6) | 0.39 | 20(12.7) | 27 (7.7) | 0.065 |
| Missing* | 7 (1.2) | 2 (1.7) | 3 (0.9) | 4 (2.5) | 4 (1.1) | ||
| T status | |||||||
| T1 | 211 (36.8) | 56 (47.1) | 97 (29.6) | 64 (40.8) | 120 (34.2) | ||
| T2 | 272 (47.4) | 46 (38.7) | 173 (52.7) | 0.002 | 71 (45.2) | 171 (48.7) | 0.26 |
| T3–4 | 72 (12.5) | 13 (10.9) | 49 (14.9) | 17 (10.8) | 51 (14.5) | ||
| Missing* | 19 (3.3) | 4 (3.4) | 9 (2.7) | 5 (3.2) | 9 (2.6) | ||
| N status | |||||||
| N0 | 307 (53.5) | 64 (53.8) | 166 (50.6) | 93 (59.2) | 182 (51.9) | ||
| N1–3 | 250 (43.6) | 53 (44.5) | 153 (46.7) | 0.62 | 62 (39.5) | 158 (45.0) | 0.18 |
| Missing* | 17 (3.0) | 2 (1.7) | 9 (2.7) | 2 (1.3) | 11 (3.1) | ||
| ER status | |||||||
| Negative | 208 (36.2) | 37 (31.1) | 124 (37.8) | 54 (34.4) | 123 (35.0) | ||
| Positive | 344 (59.9) | 79 (66.4) | 193 (58.8) | 0.17 | 93 (59.2) | 214 (61.0) | 0.96 |
| Missing* | 22 (3.8) | 3 (2.5) | 11 (3.4) | 10 (6.4) | 14 (4.0) | ||
| PgR status | |||||||
| Negative | 234(40.8) | 40 (33.6) | 136 (41.4) | 50 (31.8) | 144 (41.0) | ||
| Positive | 311(54.2) | 77 (64.7) | 181 (55.2) | 0.10 | 97 (61.8) | 191 (54.4) | 0.06 |
| Missing* | 29 (5.1) | 2 (1.7) | 11 (3.4) | 10 (6.4) | 16 (4.6) | ||
| HER2† | |||||||
| Negative | 406 (70.7) | 86 (72.3) | 236 (71.9) | 105 (66.9) | 244 (69.5) | ||
| Positive | 50 (8.7) | 6 (5.0) | 32 (9.8) | 0.14 | 9 (5.7) | 32 (9.1) | 0.28 |
| Missing* | 118 (20.6) | 27 (22.7) | 60(18.3) | 43 (27.4) | 75 (21.4) |
N, axillary lymph node; T, tumor.
*
During specimen processing, some tumor punches were lost leading to a smaller patient number per staining.
†
HER2 status was not known for all patients.