Table 1.

Clonal structure of tumors in the aggregation chimeras

						No. of tumors
Type	Mouse ID	Section	% Blue	Median distance to blue, μm	Median distance to white, μm	Total	White	Blue	Heterotypic	Not scorable	Not studied
ApcMin/+ ↔ Apc1638N/+ R26+	77	1	42	78	52	7	0	0	0	1	6
		2	40	68	43	14	0	0	0	2	12
		3	46	59	48	41	0	0	0	2	39
		4	36	78	42	59	0	0	1	1	57
		C	25	108	49	5	0	0	1	0	4
	124	1	50	60	54	7	1	0	1	5	0
		2	46	57	48	11	7	1	1	2	0
		3	30	59	31	31	29	0	0	2	0
		4	30	78	38	30	28	0	1	1	0
		C	51	43	57	11	11	0	0	0	0
	130	1	54	60	70	10	0	0	0	2	8
		2	57	42	51	13	2	0	0	3	8
		3	50	60	64	62	4	0	0	4	54
		4	52	54	57	27	1	0	0	1	25
		C	59	59	78	12	1	0	1	2	8
	136	1	38	88	57	7	2	0	1	1	3
		2	38	87	60	9	0	0	0	0	9
		3	28	86	42	53	8	0	0	1	44
		4	28	73	31	45	0	0	0	0	45
		C	18	167	51	20	3	0	0	0	17
Total						474	97	1	7	30	339
ApcMin/+ ↔ Apc+/+ R26+	88	1	78	48	115	8	4	0	2	2	0
		2	61	54	68	16	6	0	0	10	0
		3	58	54	59	4	4	0	0	0	0
		4	54	34	42	0	0	0	0	0	0
		C	50	57	54	1	0	0	0	1	0
	111	1	48	78	66	4	1	0	1	2	0
		2	35	92	51	3	0	0	1	2	0
		3	30	97	42	7	6	0	0	1	0
		4	50	57	54	3	2	0	0	1	0
		C	42	60	42	0	0	0	0	0	0
	120	1	57	72	102	2	0	0	2	0	0
		2	42	85	68	2	0	0	1	1	0
		3	34	76	43	2	0	0	1	1	0
		4	41	66	51	2	2	0	0	0	0
		C	45	72	61	0	0	0	0	0	0
Total						54	25	0	8	21	0

Sections 1–4 refer to quarters of the small intestine numbered from proximal to distal; section C refers to the colon. In all aggregation chimeras, some tumors were not scorable with complete certainty because of poor fixation, sectioning, or staining. In others, tumor multiplicity was very high so it was impractical to analyze every tumor. Because all tumors were essentially a mixture of blue and white cells and their clonal structure cannot be predicted from wholemounts, a subset of tumors from throughout the intestine was chosen randomly for histological analysis. Aggregation chimeras 77, 124, 130, 136, 88, 111, and 120 were killed at 121, 101, 94, 79, 115, 108, and 122 d of age, respectively.