Figure 1.

Human Chromosome 15q11-13 and Mouse Chromosome 7

Schematic representation of the genomic regions in the human and mouse genomes. Details of conserved linkage in human 15q11-13 and mouse chromosome 7 are shown. The paternally, maternally expressed, and nonimprinting genes were labeled with blue, red, and green, respectively. The two arrowheads (BP) represent the common breakpoints, and the two arrows represent the targeting sites of 2 loxP sequences. Genomic segments that show linkage conservation (i.e., identical gene order) in humans and mice are connected by dark shading if the gene orders are in the same direction relative to their respective centromeres. If the gene orders in the syntenic segments are in opposite orientations, they are connected by light shading.