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. 2013 Jul 10;79(1):97–110. doi: 10.1016/j.neuron.2013.05.001

Figure 8.

Figure 8

A Comparison of Average Synaptic Gain in ON and OFF Bipolar Cells under a Variety of Conditions that Modulate Dopamine Signaling in the Retina

Bar graphs showing the average amplitude (±SEM) of the SyGCaMP2 response to the brightest light in OFF (A) and ON (B) bipolar cells. The various conditions are ordered according to the expected level of dopamine receptor activation. Note that, under control conditions (9:00–11:00 a.m.), synapses of OFF bipolar cells responded to light with maximal gain equivalent to that measured in the presence of the dopamine receptor agonist ADTN. In contrast, under control conditions synapses of ON bipolar cells operated at minimum gain equivalent to that measured in the presence of the dopamine receptor agonist SCH 23390.