TABLE 1.
Condition studied | State 1 | State 2 | % Change in transcription (state 2 − state 1)/state 1 | Change in FRAP (state 2 vs. state 1) |
---|---|---|---|---|
Array state | Decondensed | Condensed | −70 | Faster (Fig. 9b) |
Agonists and antagonists | Dexamethasone | RU486 | −90 | Faster (Fig. 9c) |
Dexamethasone | Corticosterone | −50 | Faster (Fig. 9d) | |
Chaperone perturbation | Dexamethasone | Geldanamycin + dexamethasone | −70 | Faster (Fig. 5a) |
Dexamethasone | Radicicol + dexamethasone | −95 | Faster (Fig. 5c) | |
Corticosterone | Geldanamycin + corticosterone | −70 | Faster (Fig. 5e) | |
Proteasome perturbation | Dexamethasone | MG-132 + dexamethasone | +210 | Slower (Fig. 7d) |
Corticosterone | MG-132 + corticosterone | −90 | Slower (Fig. 7e) |
The level of transcription was determined by measuring the relative RNA FISH signal intensities in the nuclei of 35 to 100 individual cells.