TABLE 1.
Target genes shared by AML1-ETO, PML-RARα, and PLZF-RARα
| Category and GenBank accession no. | Name | Regulation | Regulation (fold induction)
|
>2-fold induction by TSA
|
|||
|---|---|---|---|---|---|---|---|
| PMLRARα | PLZF-RARα | AML1-ETO | U937-fusion | Kasumi-1 | |||
| Cadherin/catenin/Wnt signaling | |||||||
| Z68228 | Plakoglobin | Induced | 4.20 | 5.08 | 4.62 | − | − |
| L76702 | Protein phosphatase 2 A B56-delta | Induced | 5.54 | 3.39 | 4.16 | − | − |
| AB000895 | Cadherin FIB1 | Repressed | 0.14 | 0.06 | 0.36 | − | + |
| AB000896 | Cadherin FIB2 | Repressed | 0.26 | 0.07 | 0.31 | − | − |
| Cell surface/secreted protein/extracellular matrix | |||||||
| M16279 | MIC2 mRNA, complete cds | Induced | 3.72 | 2.42 | 2.92 | − | − |
| D83782 | KIAA0199 gene | Induced | 5.59 | 3.36 | 4.30 | − | − |
| AF008445 | Phospholipid scramblase | Repressed | 0.03 | 0.03 | 0.07 | − | − |
| S76942 | Dopamine D4 receptor | Repressed | 0.04 | 0.47 | 0.12 | + | − |
| Y00787 | Monocyte-derived neutrophil chemotactic factor | Repressed | 0.11 | 0.11 | 0.22 | − | − |
| AB098642 | Semaphorin E | Repressed | 0.13 | 0.08 | 0.16 | − | − |
| M92302 | Calcium channel, voltage-gated, beta 1 subunit | Repressed | 0.16 | 0.10 | 0.04 | + | − |
| AB98642 | Osteomodulin | Repressed | 0.17 | 0.02 | 0.09 | − | − |
| L14561 | Atpase, Ca2+ transporting, plasma membrane 1 | Repressed | 0.21 | 0.23 | 0.19 | − | − |
| D79206 | Ryudocan core protein | Repressed | 0.22 | 0.06 | 0.13 | + | − |
| M32578 | MHC class II HLA-DR beta-1 mRNA (DR2.3) | Repressed | 0.26 | 0.17 | 0.06 | − | − |
| AF014958 | Chemokine receptor X | Repressed | 0.28 | 0.07 | 0.16 | − | + |
| AF000562 | Uroplakin II | Repressed | 0.45 | 0.23 | 0.32 | − | + |
| Myeloid differentiation | |||||||
| U32645 | Myeloid elf-1-like factor | Repressed | 0.22 | 0.07 | 0.07 | − | − |
| M13207 | Granu ocyte-macrophage colony-stimulating factor 1 | Repressed | 0.29 | 0.25 | 0.06 | + | + |
| M97796 | Helix-loop-helix protein (Id-2) | Repressed | 0.30 | 0.42 | 0.17 | − | − |
| M26683 | Gamma interferon | Repressed | 0.36 | 0.42 | 0.23 | − | − |
| Transcription/chromatin/ nuclear proteins | |||||||
| X73358 | hAES-1 mRNA | Induced | 61.77 | 54.95 | 54.95 | − | − |
| Z36714 | Cyclin F | Induced | 30.13 | 20.07 | 14.67 | − | − |
| M31523 | Human transcription factor (E2A) | Induced | 5.77 | 4.16 | 4.22 | − | − |
| U65093 | msg1-related gene 1 (mrg1) | Induced | 2.10 | 2.63 | 3.26 | − | − |
| X70683 | SOX-4 protein | Induced | 2.09 | 2.01 | 2.48 | − | − |
| U61145 | Enhancer of zeste homolog 2 (EZH2) | Repressed | 0.24 | 0.32 | 0.18 | − | − |
| AB000905 | H4 histone | Repressed | 0.30 | 0.29 | 0.28 | − | + |
| D87673 | Heat shock transcription factor 4 | Repressed | 0.33 | 0.04 | 0.05 | + | + |
| X79200 | SYT-SSX, synovial sarcoma translocation junction | Repressed | 0.34 | 0.43 | 0.24 | − | + |
| Z49825 | Hepatocyte nuclear factor 4 alpha | Repressed | 0.34 | 0.31 | 0.29 | − | + |
| Other or unknown function | |||||||
| D63391 | Platelet-activating factor acetylhydrolase IB gamma | Induced | 39.56 | 31.36 | 20.04 | − | − |
| D31764 | KIAA0064 gene | Induced | 6.66 | 6.31 | 3.91 | − | − |
| M57567 | ADP-ribosylation factor (hARF5) | Induced | 3.06 | 2.17 | 2.31 | − | − |
| L36983 | Dynamin (DNM) | Induced | 3.42 | 2.23 | 3.08 | − | − |
| D16480 | Mitochondrial enoyl-coenzyme A hydratase | Induced | 2.76 | 3.42 | 2.54 | − | − |
| AB000467 | RES4-25 | Repressed | 0.00 | 0.00 | 0.01 | − | − |
| AB000466 | RES4-24C | Repressed | 0.01 | 0.01 | 0.01 | − | − |
| U60206 | Stress-responsive serine/threonine kinase Krs-1 | Repressed | 0.03 | 0.04 | 0.04 | − | − |
| AB000450 | VRK2 | Repressed | 0.03 | 0.04 | 0.10 | − | − |
| U57450 | EPC-1 gene | Repressed | 0.06 | 0.33 | 0.33 | + | − |
| AB000449 | VRK1 | Repressed | 0.08 | 0.07 | 0.11 | − | − |
| D49818 | mRNA for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate | Repressed | 0.09 | 0.21 | 0.02 | − | − |
| U92015 | Defective mariner transposon Hsmar2 | Repressed | 0.14 | 0.10 | 0.14 | + | + |
| D31897 | Doc2 (double C2) | Repressed | 0.17 | 0.07 | 0.14 | − | − |
| U87964 | Putative G-protein (GP-1) | Repressed | 0.18 | 0.18 | 0.05 | + | − |
| AB000115 | Human mRNA expressed in osteoblast | Repressed | 0.18 | 0.17 | 0.19 | − | + |
| AB000462 | SH3 binding protein, clone RES4-23A | Repressed | 0.20 | 0.11 | 0.12 | − | − |
| K03183 | Chorionic gonadotropin beta subunit | Repressed | 0.28 | 0.05 | 0.30 | + | − |
| AB000409 | MNK1 | Repressed | 0.29 | 0.27 | 0.38 | + | − |
| AB002314 | KIAA0316 | Repressed | 0.37 | 0.16 | 0.17 | − | + |
| M16750 | Pim-1 oncogene | Repressed | 0.44 | 0.27 | 0.09 | + | + |