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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Br J Ophthalmol. 2011 Mar 18;95(11):1496–1501. doi: 10.1136/bjo.2010.194241

Figure 3.

Figure 3

Schematic of the major enzymatic pathways metabolising ω3-polyunsaturated fatty acids (PUFAs). Phospholipase A2 (PLA2) liberates ω3-PUFAs (eg, docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) from the cell membrane. These lipids are rapidly further metabolised by cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (Cyp450) enzymes, generating the pathway-specific lipid metabolites 3-series prostaglandins, hydroxydocosahexaenoic acids (HDHAs), resolvins, neuroprotectins, epoxyeicosatetraenoic acids (EpETEs) and epoxydocosapentaenoic acids (EpDPEs).