Fig. 5. Schematic representation of the role of Wnt7a-induced hsa-miR29b expression in NSCLC proliferation.

Wnt7a/Fzd9 signaling leads to induction hsa-miR29b, which is mediated by ERK5 and PPARγ. The hsa-miR29b expression targets MDM2 mRNA to degradation, which results in increased p53 levels and reduced cell proliferation. In NSCLC, on the contrary, absence of Wnt7a fails to activate Wnt7a/Fzd9 pathway, which blocks induction of hsa-miR29b expression. Loss in hsa-miR29b expression results in increased MDM2 levels reduced p53 expression and increased cell proliferation.