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Suppression of promoter activities of steroidogenic-enzyme genes by TNF-α. TNF-α inhibited the LH-induced promoter activities of StAR, P450c17, and β-HSD genes. K28 cells were transiently transfected with the indicated luciferase reporter genes and treated (+) with 100 ng of LH/ml and 10 ng of TNF-α/ml for 24 h. The error bars indicate standard deviations.
