Table 2.

Biodistribution of ¹¹¹In-labeled Ac-TZ14011-DTPA (11), monomer Ac-TZ14011-MSAP (3), dimer (Ac-TZ14011)₂-MSAP (7), tetramer (Ac-TZ14011)₄-MSAP (10) and MSAP label (1) in MIN-O tumor bearing mice at 24 h post injecting.

	uptake (%ID/g)
tissue	Ac-TZ14011- DTPA (11)	MSAP label (1)	monomer Ac- TZ14011-MSAP (3)	dimer (Ac- TZ14011)2-MSAP (7)	tetramer (Ac- TZ14011)4-MSAP (10)
Blood	0.01 ± 0.00	0.32 ± 0.09**	0.14 ± 0.02***	0.14 ± 0.03**	0.11 ± 0.01***
Brain	0.00 ± 0.00	0.03 ± 0.01	0.02 ± 0.00	0.03 ± 0.01	0.02 ± 0.00
Lungs	0.13 ± 0.02	0.65 ± 0.18**	1.02 ± 0.13***	2.13 ± 0.60**	1.68 ± 0.31**
Heart	0.05 ± 0.00	0.64 ± 0.12**	0.89 ± 0.22**	0.60 ± 0.12**	0.43 ± 0.06***
Liver	5.08 ± 0.52	5.76 ± 1.11	22.46 ± 5.46**	30.59 ± 5.45**	22.43 ± 0.67***
Kidneys	27.07 ± 0.74	6.49 ± 2.99***	7.50 ± 1.39***	6.46 ± 1.36***	4.37 ± 0.52***
Spleen	1.14 ± 0.32	0.93 ± 0.13	4.76 ±1.23**	7.01 ± 1.45**	4.66 ± 0.46***
Stomach	0.06 ± 0.01	0.81 ± 0.45*	0.81 ± 0.16**	0.97 ± 0.52*	1.09 ± 0.52*
Intestines	0.10 ± 0.01	1.02 ± 0.31**	1.85 ± 0.08***	2.06 ± 0.26***	1.56 ± 0.46**
Tumor	0.19 ± 0.03	n.d.	1.10 ± 0.60	0.57 ± 0.19*	0.42 ± 0.10*
Muscle (paw)	0.03 ± 0.00	0.22 ± 0.06**	0.31 ± 0.01***	0.07 ± 0.03	0.08 ± 0.02*

The significance with respect to ¹¹¹In-labeled Ac-TZ14011-DTPA (11) is indicated by the asterisks (* = P < 0.05, ** = P < 0.01, *** = P < 0.001).