Skip to main content
. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Neurochem. 2012 Jan 23;120(5):779–794. doi: 10.1111/j.1471-4159.2011.07620.x

Figure 1.

Figure 1

Effects of DAMGO pretreatment on methamphetamine-induced arc mRNA expression in the rostral striatum, 45 minutes post-treatment. In situ hybridization films (A) showing arc mRNA expression in the rostral striatum. Note the homogenous pattern of arc mRNA expression in methamphetamine-treated animals, and the similar levels of arc mRNA expression between vehicle- and DAMGO-pretreated methamphetamine-treated animals. Quantitative analysis of arc mRNA expression in the patch and matrix compartments of dorsolateral (B), dorsomedial (C), ventrolateral (D) and ventromedial (E) striatum, from rats intrastriatally infused with vehicle or DAMGO (1 μg/μl) 15 minutes prior to treatment with methamphetamine (0.5 mg/kg). Quantitative values are average gray values (arbitrary units, ±SEM, n=5–8 animals). There was a significant overall main effect of methamphetamine treatment in the patch and matrix compartments of all four sub-regions of striatum.