Table 1.
Subunits of cohesin complexes and cohesin regulators implicated in cohesinopathies
| Saccharomyces cerevisiae | Schizosaccharomyces pombe | Drosophila | Xenopus | Mammals | |
|---|---|---|---|---|---|
| Structural maintenance of chromosomes (SMC) | Smc1 | Psm1 | Smc1 | XSMC1 | SMC1α |
| Smc3 | Psm3 | Cap/Smc3 | XSMC3 | SMC3 | |
| Meiosis-specific | SMC1β | ||||
| α-kleisin (from Greek for “closure”) | Mcd1/Scc1 | Rad21 | DRad21 | XRAD21 | RAD21 |
| Meiosis-specific | Rec8 | Rec8 | XREC8 | REC8, RAD21L | |
| Stromalin/HEAT repeat domain | Scc3/IRR1 | Psc3 | DSA1 | XSA1, XSA2 | STAG1, STAG2 |
| Adherin (loading) | Scc2 | Mis4 | Nipped-B | Nipbl/Scc2/delangin | NIPBL/SCC2/DELANGIN |
| Scc4 | Ssl3 | Mau2/Scc4 | MAU2/SCC4 | ||
| Regulator (maintenance) | Pds5 | Pds5 | Pds5 | PDS5A | PDS5A |
| PDS5B/AS3/Aprin | PDS5B/AS3/APRIN | ||||
| Cohesin acetyltransferase (establishment) | Eco1/Ctf7 | Eso1 | Eco/Deco San |
Esco1 Esco2 |
ESCO1 ESCO2 |
| Cohesin deacetylase | Hos1 | ? | ? | Hdac8 | HDAC8 |