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Anti-HIV-1IIIB activity of 4′-carbon-substituted stavudine 76-78a
| Compd | IC50 (μM)a | IC50 (μM)b |
|---|---|---|
| 76 | > 100 | > 100 |
| 77 | > 100 | > 100 |
| 78 (4′-ethynylstavudine) | 0.20 | > 100 |
| stavudine | 2.8 | 100 |
Data taken from ref. 33.
Inhibitory concentration required to achieve 50% protection of MT-2 cells against the cytopathic effect of HIV-1 IIIB.
Cytotoxic concentration required to reduce the viability of mock-infected MT-2 cells by 50%.
