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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Curr Pharm Des. 2013;19(10):1880–1897. doi: 10.2174/1381612811319100011

Table 6.

Anti-HIV-1 activity of 4′-Ed4T against multidrug-resistant clinical isolates in PBMCsa,b

Virus Tropism EC50 (μM) Mutations associated with NRTI resistancec
KK R5 0.020 ± 0.008 Isolated from a treatment-naive patient
HKW R5 0.35 ± 0.02 M41L, V75L, D67N, M184I, T215Y, K219R
HNK R5 0.089 ± 0.052 D67N, T69D, K70R, M184V, T215F, K219D
HTN R5 0.27 ± 0.15 M41L, M184I, T215Y, K219R
HTK X4 0.15 ± 0.08 M41L, L74V, M184V, T215Y
a

Data from reference 35.

b

Except for HKW, all data represent means ± SD for three or four separate experiments. For HKW, the EC50 represents the mean ± range for two separate experiments.

c

Mutations of HKW, HTK, HTN, and HNK were determined by Oka et al. (unpublished data).