Table 7.
Anti-HIV-1 activity of 4′-Ed4T against wild-type and drug-resistant mutantsa
| Strain | EC50 (μM)b
|
|
|---|---|---|
| 4′-Ed4T | 3TC | |
| IIIB (wild type) | 0.22 ± 0.13 (1) | 2 ± 0.8 |
| IIIB (3TC29D) | 0.41 ± 0.08 (1.8) | > 20 |
| IIIB (4′-Ed4T26D) | 0.39 ± 0.13 (1.7) | > 20 |
| IIIB (4′-Ed4T81D) | 2.3 ± 1.4 (10) | > 20 |
| CC50(μM)c | > 20 | > 20 |
a
All data represent means ± standard deviations for three separate experiments
b
EC50: 50% effective concentration based on the inhibition of virus-induced cytopathicity in MT-4 cells
c
CC50: 50% cytotoxic concentration based on the reduction of viable cell number in mock-infected MT-4 cells