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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Circ Res. 2013 Jul 5;113(2):100–103. doi: 10.1161/CIRCRESAHA.113.301577

Figure 2. Nitric oxide metabolism and S-nitrosothiol formation.

Figure 2

Figure 2

(A) Nitric oxide (NO.) is synthesized by the nitric oxide synthases (NOS), and can undergo oxidation to nitrite and nitrate, react with superoxide anion (.O2) to form peroxynitrite (ONOO−), or bind to transition metals (NO-M). Three different mechanisms of trans-S-nitrosylation are indicated, as well as denitrosylation steps. Detailed reaction mechanisms for key reactions highlighted in blue are provided in (B). [Reproduced with agreement by Mary Ann Liebert Publisher, Inc., which does not require formal permission to obtain approval for personal reuses (reference 14).]