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. 2013 Apr 17;33(16):6742–6752. doi: 10.1523/JNEUROSCI.0528-13.2013

Figure 1.

Figure 1.

Integrin α3 is enriched at the synaptic plasma membrane (SPM), and its genetic loss does not disrupt overall hippocampal structure. A, Immunoblot of a synaptic fractionation from P42 WT mouse forebrain demonstrating that integrin α3 is enriched at the SPM fraction relative to crude homogenate (C), synaptoneurosome (SN), and synaptic membrane (SM) fractions. PSD95 is used as fractionation control for enrichment of SPM-associated proteins. B, Immunoblot of C and SM fractions reveals a significant reduction of integrin α3 expression in NEX–α3−/− forebrain compared with WT at P42. C, Immunohistochemistry staining using NeuN on P42 hippocampal sections shows grossly normal hippocampal structure in WT, NEX–α3−/−, and arg+/−α3+/− mice. Scale bar, 200 μm.